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Animal studies showed retatrutide producing lower expression levels of inflammatory and fibrotic mediators compared to tirzepatide, suggesting the triple mechanism may offer benefits beyond additional weight loss
Mechanism: Both stimulate growth hormone release, but the DAC version has a longer half-life, allowing for less frequent dosing
It is also particularly valuable for patients who may have issues with their digestive system that may make other forms of increasing their B12 levels, such as pills and food, less effective
10.1586/eem.10.73 Expert Rev
