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Additionally, there are drug efflux pumps such as p -glycoprotein (P-gp), multidrug resistance associated protein (MRP) and drug metabolic enzymes, at the BBB to remove and/or inactivate small drug molecules from the brain [1]
There was also an apparent impact of the ACore alone to increase spine density and the PSD count
These proteins are then directed to the lysosomal receptor LAMP2A for translocation and subsequent degradation [5]
Another possible weakness was the relatively low mean beta OHB level (1.19) in the KD group
