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This glutathione depletion is not merely a consequence of the disease - it is thought to be a contributing driver of disease progression, creating a vicious cycle: oxidative stress depletes glutathione reduced glutathione allows more oxidative damage more protein oxidation stronger autoimmune response more thyroid destruction more oxidative stress
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The best illustration of this fact is given by X-ray crystallography, which serves as the primary tool for determining the 3D atomic structure of proteins
Unsupervised clustering was performed on immunophenotyping data using FlowSom analysis of fcs files gated on CD45+ cells with the OMIQ software from Dotmatics (www.omiq.ai, www.dotmatics.com)
