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For infertile patients and those with history of recurrent miscarriage who do not have an underlying autoimmune disease, suppressing the maternal immune system with medications has for the most part not been successful in improving implantation or preventing miscarriage

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[1] Spike-timing-dependent plasticity (STDP), where a presynaptic neuron firing just milliseconds before a postsynaptic neuron leads to synaptic strengthening (timing-based long-term potentiation LTP), while firing after the postsynaptic neuron causes weakening (timing-based long-term depression LTD)