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Concluding remarks Many of the foundational studies of the ascorbateglutathione pathway in the 1970s and 1980s were conducted in plant species such as spinach and pea

ROS have been implicated in a number of pathologic processes, including reperfusion injury, cancer, inflammatory disease, and aging
HFD induces insulin resistance, while a low dose of STZ results in mildly impaired -cell function [90, 91]
Defects in ROS production allow bacteria to survive and repeatedly colonize various tissue sites as well as to cause septicemia (Baehner and Nathan, 1967
