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doi: 10.1007/s00018-015-2070-4 62
They can occur multiple times daily, significantly impacting a womans daily life, sleep quality, and overall well-being
Based on this the use of phosphate buffer, pH 7.4, was suggested by Silk et al to reduce the undesirable non-enzymic hydrolysis to negligible proportions despite of a pH optimum of 8.5 26
