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These structural changes are underpinned by activation of the PGC-1/fibronectin type III domain-containing protein 5 (FNDC5)/BDNF axis, with prolonged endurance training boosting BDNF synthesis across multiple brain regions [29]
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doi: 10.1016/j.cbi.2019.02.013
It is also the most common excitatory (stimulating) neurotransmitter in the central nervous system
