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Depending on the cell state, but especially presence of oxidative stress, MTs are rapidly translocated to the nucleus through nuclear pore complexes
Cytochrome P450 enzymes mediate tamoxifen biotransformation, CYP3A4, CYP2B6, CYP2C9, CYP2C19 and CYP2D6 are the essential isoenzymes for this process
An ion-pair, K26/D79, located in the lipid bilayer region connects TM1 and TM2 (Supplementary Fig
They amplify results through complementary cellular actions rather than replacing these conventional approaches
