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A 2012 Cochrane Review of pooled data from three trials examining tracheostomy-free survival in 974 patients treated with riluzole and 503 placebo-treated patients demonstrated a statistically significant increase in survival from 11.8 months to 14.8 months, but without any benefit on measures of muscle strength
It increases ROS expression by promoting P53 acetylation, driving macrophage differentiation into the M1 phenotype (Zhou et al., 2018)
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control FoB ( Gclc fl/fl Mb1-cre + FoB vs
