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We used the Clopper-Pearson method to calculate point estimates and two-sided 95% exact confidence intervals for rates of sustained virologic response for the sofosbuvir-velpatasvir group as a whole, as well as according to HCV genotype (1a, 1b, 2, 4, 5, or 6), and various subgroups

Celestino-SoperPBSViolanteSCrawfordELLuoRLionelACDelabyEet al

The discovery by Virchow more than 100 years ago that atheroma contained a yellow fatty substance, later identified as cholesterol by Windaus, suggested a role for lipids in the pathogenesis of atherosclerosis (2)