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Additionally, as a hydrophilic molecule, DFO has a poor cell permeability and tends to remain in extracellular fluid, which may still limit its efficacy (Hanson et al., 2009
[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Thibault R., Coffier M., Joly F., Boh J., Schneider S
10.1016/j.cbi.2005.12.009 99 WadaT.PenningerJ
Furthermore, the increment of ROS content along with the oxidative stress markers increase are suggestive of a putative activation of the p38, ERK MAPK signaling pathway (Torres, 2003)
