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Cancers (Basel) 13 , 125 (2021)
Bee venom improved the sleep index in scleroderma patients [42]

Notably, the three-dimensional structure indicates that OsDHAR contains a broad, uncharged cleft between the 2-helix and the 3-helix as the putative binding site for non-native protein folding intermediates for its chaperone-like activity

However, the conservative approach is waiting until skeletal maturity and the early 20s when growth plates are fully closed and endocrine systems are mature
