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Perilla seed oil is rich in Omega-3 fatty acids, manifested by decreased ROS levels, stable mitochondrial membrane potential, and increased ATP levels, provides healthy activity for the brain ( 4.5 Gut microbiome-brain axis regulation The regulation of the gut microbiota-brain axis constitutes a reciprocal communication network
Activated inflammatory cells, e.g
affect the function of CNS through central cholinergic and dopaminergic nerves, and the decline of learning and memory ability is often accompanied by the changes in neurotransmitter levels in related brain regions
In addition, the PPA model demonstrated that pentoxifylline intervention resulted in augmented neuronal density in CA1 and CA3 of the hippocampus, elevated Purkinje cell numbers, and diminished GFAP immunoreactivity and IL-17 and TNF- levels in the brain [96]
