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These stages are based on factors that include: Tumor thickness or how deep melanoma is found in the skin If the tumor has cracked or broken through the top layer of the skin (ulcerated) If the tumor has spread to lymph nodes If the tumor has spread to other parts of the body Treatment of melanoma Treatment for melanoma depends on the: Location of the melanoma Features of the tumor (gene changes and histology) Stage of disease Surgery is the main treatment for melanoma