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Exposure to environmental toxins used in industrial applications, including polyaromatic hydrocarbons and polyhalogenated biphenyls, can also trigger thyroid autoimmunity (Zaletel And Gaberscek 2011)

In September 2023, FDA placed "Thymosin Beta-4, Fragment (LKKTETQ)," the substance sold as TB-500, on Category 2 of its interim 503A bulk drug substances list, meaning FDA identified significant safety concerns and would not permit licensed compounding pharmacies to use it