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Description
Activated p53 promotes pro-apoptotic signaling by upregulating Bax, Bak, and Noxa while downregulating anti-apoptotic proteins such as Bcl-2, Bcl-xL, and Survivin [212,213,214]
None of these mechanisms overlap
Early detection and treatment are critical for preventing severe complications
In this case I stop, change needles and choose another site
