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[4] Perhaps the most notable role of glutathione is how it supports detoxification.* Specifically, glutathione is essential for phase II detoxification, which acts directly on the harmful substances within the body that have been partially broken down in phase I, like heavy metals.* This process is called conjugation and is made possible by glutathione.* These four functions of glutathione are only some examples of the critical roles it plays in the body.* There are several contributing factors that may lead to depleted levels of glutathione, such as harmful substances within the body, everyday stress, genetics, overuse of alcohol or other substances, smoking, as well as aging

10.1093/brain/awl118 369 Writing Group on Behalf of the Edaravone (MCI-186) ALS 19 Study Group

(2020) 36:e3213

It is conditionally essential the body can produce it from methionine, but the pathway has limits