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Thus, based on the prior data and the findings from the current study, we propose that mitochondrial dysfunction is a key event in the neurodegeneration associated with MSS
Moving forward, understanding proteostasis at a systems level, as an interactome rather than a pathway, will be essential for decoding disease mechanisms and designing truly effective therapeutic interventions

Corrinoids are known to play a key role as modulators of the microbiome and the availability and integration of cobalt into the corrin-framework is a key step in the health of this large and complex ecosystem [232]

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