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Curcumin triggered down-regulation on PKM2 via mTOR-HIF-1 inhibition in H1299 nonsmall cell lung cancer cells, MCF7 breast adenocarcinoma cells, HeLa cervical adenocarcinoma cells, and PC-3 prostate adenocarcinoma cells, reversing the Warburg effect [127]

Finally, there are other neurotrophic factors that have shown dopaminergical neuronal protection in Parkinson-like models, including hepatocyte growth factor (HGF), mesencephalic astrocyte-derived neurotrophic factor (MANF), cerebral dopaminergic neurotrophic factor (CDNF), granulocyte colony-stimulating factor (G-CSF), and platelet derived growth factor (PDGF-CC) [31-32, 135-136]

[DOI] [PubMed] [Google Scholar] 26.Aher, V