lips-14 c elegans Application of Caenorhabditis in Lipid Metabolism Research Lipid Oxidation at the Crossroads:

Marko DM, Conn MO, Schertzer JD

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Not only is SP-C crucial for stabilizing cholesterol-containing surfactant films ( In vitro studies demonstrated that SP-C attenuates LPS induced cytokine production via TLR-4 signaling in a macrophage cell line, suggesting SP-C to play a role in innate immunity ( Assuming this hypothesis (Figure 3), SP-C deficiency could predispose to TLR-4 activation by various oxidized cholesterol and PL species as well as their uptake

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