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The following data were collected: publication year, country and continent, study setting (e.g., hospital, private practice, academic clinic), sample size, age range, mean age, study design, population characteristics, intervention details, outcomes, and effect measures (e.g., serum B12 levels)

In the foundational mouse study, MOTS-c prevented diet-induced obesity and reversed insulin resistance without changes in food intake or exercise (Lee et al

Benefits typically last from one to three weeks, depending on lifestyle, diet, and individual metabolism

Other Considerations: Monitoring: Regular monitoring of vitamin B12 levels, complete blood counts, and neurological function is advisable, especially in long-term use