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A vitamin B12 deficiency can disrupt several systems in the body, causing fatigue, dizziness, shortness of breath, confusion, vision loss, and even depression

Adedara AO, Babalola AD, Stephano F, Awogbindin IO, Olopade JO, Rocha JBT, Whitworth AJ, Abolaji AO (2022) An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster

However, the measurement of the ratio of [GSH]:[GSSG] in an intracellular organelle is fraught with technical difficulties

The effects are very sustainable, though reversible, i.e., the skin could gradually regress to its original colour when the supplementation and supportive habits are discontinued