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Examination of AUD subjects who began drinking before the age of 21 revealed that BDNF-AS trended towards being significantly correlated with alcohol use per day at time of death ( r = 0.567, p = 0.069), but this was not the case for controls ( r = 0.212, p = 0.37) or in the late onset group ( r = 0.258, p = 0.45) (Supplementary Fig

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