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When skin is rough, dead cells build up and scatter light, making it appear dull and tired
Those with MTHFR gene mutations lack the enzyme required to activate folic acid, which can result in a buildup of unmetabolized folic acid (UMFA)
In addition, the K-Ras, B-Raf, and c-Myc oncogenes can transcriptionally induce Nrf2, and miRNAs can target NFE2L2 or the 3 UTR of KEAP1 mRNA [69]
