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Reactions were performed with 5 M histone H3 (histone L-arginine) substrate, 1 M radiolabeled S-adenosyl-L-[methyl- 3 H] methionine (SAM) co-substrate, and recombinant human PRMT3 enzyme

The difference between effective dosing and throwing money into subcutaneous fat comes down to understanding molarity, concentration math, and the biological ceiling at which NNMT inhibition plateaus

They can cause significant muscle loss along with fat loss, which some research suggests may be as high as 30-40% of total weight lost
