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10.3389/fcell.2019.00271 [DOI] [PMC free article] [PubMed] [Google Scholar] Date K., Matsumoto K., Kuba K., Shimura H., Tanaka M., Nakamura T

149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages

B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from pernicious anaemia, Crohns or celiac disease

Metabolism 47 : 14811489 Morrow LA et al