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A key feature is ECM degradation, which results from the upregulation of MMPs and ADAMTSs, leading to the breakdown of proteoglycans and collagen, ultimately causing structural damage to the intervertebral disc (36,37)

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Aging 13 (23), 2551825549

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doi: 10.1093/carcin/bgaa001 127 KlutznySAnurinANickeBReganJLLangeMSchulzeLet al

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