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Most of the GCL holoenzyme can be reversibly dissociated by treatment with dithiothreitol [42], while oxidative stress may enhance holoenzyme formation as it increases GCL activity in the absence of any change in the expression of GCL subunits [45]
For example, internalized IGF-1R can upregulate the expression of the oncogene JUN and enhance the recruitment of RNA Pol II to JUN promoter regions, which is beneficial to cell survival (Figure 2) [36]
Luque-Ceballos, Penlope Rodrguez-Zamora, Juan Carlos Lpez-Olivos, Ignacio L
10.2478/v10102-012-0009-2 Interdiscip
