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However, it is becoming increasingly clear that interactions between different species in a biofilm can modulate the overall antimicrobial tolerance of the community, and that these multispecies interactions may be clinically relevant as many infections are polymicrobial in origin [ Toxin-Antitoxin System and Its Significance in Phenotypic Switching in Biofilms Bacterial toxin-antitoxin systems (TAs) are a set of genetic elements present in bacterial cells that encode for a toxin and its corresponding antitoxin

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Apart from the GPX4, extensive studies have shown that iron was also involved in the development of atherosclerotic lesion through affecting LPO in vitro and in vivo [74, 75]

It is essential for collagen synthesis, immune function, and the repair and maintenance of various tissues, including the liver