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153 Noise can damage cochlear tissues through a variety of mechanisms that are also factors in age-related hearing loss, such as increased inflammation and free radical production, disordered calcium metabolism in the inner ear, altered cell signaling, and programmed cell death, all of which have been implicated in hair cell and auditory neuron damage
From the evidence of Mao et al, interleukin-6, tumor necrosis factor-, and interleukin-1 in serum levels of DM-associated ED rats were increased, while interleukin-10 and interleukin-4 were decreased [85]

If corneal damage is suspected, fluorescein stain should be used to assess the cornea

Research has shown meaningful improvements in quality of life, pain management and physical function