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Alfieri, A

By suppressing the expression of anterior pharynx-defective-1alpha and -1beta and inhibiting the aggregation of beta-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

Concurrently, ER can induce autophagy independently of classical pathways (mTOR, PI3KCIII, MAPK) via regulators such as BAG3, ATG7, and WIPI, while ER modulates autophagy in a context-dependent manner, influencing autolysosome formation, cyclin degradation, HIF function, and interacting with autophagy-related proteins (ULK1, BECN1, LC3B, ATG16L1, p62) and the NLRP6 inflammasome

P.Larson-PriorL.KrystalA