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Statements regarding biological activity reflect preclinical and in vitro findings only and have not been evaluated by the U
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Multiple sessions may be recommended for the best outcome
Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype
