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3.5 Macrophages from vaccinated groups, alone or incubated with unprimed PBMCs, have better MAP killing activities than their homologs from wild-type group A bacterial viability assay was employed to evaluate the killing activity of macrophages alone, macrophages incubated with primed PBMCs, and macrophages incubated with unprimed PBMCs

The proposed mechanisms range from well-validated (FDA-approved GLP-1 agonists for weight loss) to highly speculative (epitalon, thymosin alpha-1, MOTS-c) with limited or no human clinical validation

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