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Owing to severe injury or congenital deformity, osteogenesis insufficiency, rheumatoid arthritis or osteoporosis, the long and limited self-healing process of bone grafts cannot fully meet the requirements of timely bone regeneration sometimes [3-5]

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CVD was defined as non-fatal myocardial infarction and/or stroke (haemorrhagic or ischemic) (PROLONG-Sweden, PROLONG-Denmark) and balloon angioplasty or coronary artery bypass surgery (DIALONG)