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Moreover, high amounts of Pt 2+ were identified in the kidneys of the above-mentioned mice, suggesting that Pt 2+ from MnO 2 /[email protected] NPs was quickly cleared by the kidneys

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3.2 Pyroptosis: a pro-inflammatory cell death process that promotes bone destruction Driven by the same inflammatory and hypoxic stresses that stabilize HIF-1, pyroptosis emerges as a pro-inflammatory programmed cell death mediated by inflammatory caspases, primarily Caspase-1, Caspase-4/5 (in humans), and Caspase-11 (in mice)