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In addition, probiotics improve the function of phagocytes and NK cells, trigger apoptosis in T cells, increase anti-inflammatory cytokines (such as IL- 10 and TGF-), and reduce pro-inflammatory cytokines (such as TGF- and IFN-) [152, 153]

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Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue