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Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis

However, their clinical application requires rigorous evaluation of therapeutic efficacy, comprehensive safety profiling, and well-defined patient selection criteria

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PE-22-28 inhibits TREK-1 channels with an IC50 of 0.12 nM, compared to 40-60 nM for its parent compound spadin