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Cuproptosis: Lipoylated TCA cycle proteins-mediated novel cell death pathway

This superoxide is rapidly converted into hydrogen peroxide (HO), which, in the presence of Fe 2+ , generates highly reactive hydroxyl radicals (OH) through the Fenton reaction

[198] [200] [196] Because conventional PKC isoforms can be activated by Ca 2+ and diacylglycerol, elevated intracellular calcium can promote PKC-dependent DAT phosphorylation independent of TAAR1

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