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This model involves the activation of innate immune cells within the brain, but T and B lymphocytes do not play a central role (Wolf, 2018), thereby distinguishing it from other MS models that involve the adaptive immune system, such as Experimental Autoimmune Encephalomyelitis (EAE), Theilers Murine Encephalopathy Virus (TMEV), and other viral models of MS (Dedoni, 2023)

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Also note that high intake of folic acid can mask B12 deficiency and exacerbate anemia