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As such, it is apparent that additional experimentation focusing on genomics, environmental/nutritional components and their crosstalk is warranted to determine the causal factor(s) that reduce both cystine and selenoprotein levels in children affected with konzo to unravel the biological mechanism behind this disease
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82 Subnormal ALP levels have also been correlated with the presence of Coombs (+) hemolytic anemia, but were not found to be related to excess copper per se in the bloodstream

There are also pharmacologic molecules that can induce or inhibit autophagy via mTOR-independent mechanisms (81)
