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A number of mercapturates derived from halogenated alkenes are converted to the corresponding sulfoxides by cytochrome P450 3A (but apparently not by FMOs) (Birner et al., 1998, Werner et al., 1995a, Werner et al., 1995b, Werner et al., 1996)
This mechanism regulates intestinal stem cell proliferation, regeneration, and differentiation, as confirmed in both in vitro organoid and in vivo aging models

Retinoids remain effective but require a gentler introduction
[DOI] [PubMed] [Google Scholar] 141.Saad S., Ahmad I., Kawish S.M., Khan U.A., Ahmad F.J., Ali A., Jain G.K
