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CLASSIFICATION OF DRUGDRUG INTERACTIONS Additivethe combined effect of 2 drugs equals the sum of the effect of each agent given alone Synergisticthe combined effect of 2 drugs exceeds the sum of the effects of each drug given alone Potentiationthe creation of a toxic effect of 1 drug due to the presence of another drug Antagonismthe interference of 1 drug with the action of another drug Chemical antagonismreaction between 2 chemicals to neutralize their effects Dispositional antagonismalteration of the disposition of a substance so that less of the agent reaches the target organ Receptor antagonismblockade of the effect of 1 drug with another drug that competes at the receptor site A 20-year-old man goes to a college party