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Mechanistically, circadian control of CI probably reflects the intersection of substrate routing and time-of-day coordination of CI biogenesis, stability and activity
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More research is needed to fully understand the potential effects and applications of DSIP in humans
Following its dissociation from the a 2 -macroglobulin, the peptide is proteolytically cleaved to generate a C-terminal pentapeptide, which activates an intracellular Gi-protein-MAP kinase signalling pathway [232, 233]
