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Emerging data from longitudinal cohort studies are also enhancing our understanding of these processes, with potential implications for both the treatment of CKD-related cognitive decline and the broader issue of cognitive dysfunction in ageing populations

As COX17 serves as a primary copper donor in the IMS, 83 mutations in COX17 can reduce CCO activity and cause mitochondrial dysfunction and oxidative stress, 84 further supporting coppers significance in mitochondria

IGF-1 LR3 is a modified version of natural IGF-1 with two engineered changes: a 13-amino-acid N-terminal extension and an arginine substitution at position 3

Angiogenesis is vital for supplying oxygen and nutrients to the site of injury, facilitating tissue repair and regeneration