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Because some researchers may not have tested the mechanisms by which drugs modulate synaptic plasticity in relation to neurexins, and some drugs with potential for sustained antidepressant effect based on the modulation of synaptic plasticity by neurexins may have been overlooked

Disruption of this inhibitory interaction allows increased nitric oxide production, which is relevant to endothelial signaling and vascular responsiveness in experimental systems [3]

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Aihara K, Hirayama A, Tanaka N et al: Hydrodistension under local anesthesia for patients with suspected painful bladder syndrome/interstitial cystitis: Safety, diagnostic potential and therapeutic efficacy