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24 h after MCAO/R, iron supplementation directly increased the volume of cerebral infarction in rats, 727 and iron deposits were detected in microglia at 3 weeks after MCAO/R and in the parenchyma at 7 weeks after MCAO/R
Because of the redundancy of the intracellular networks involved, the initial enthusiasm for the development of a single target therapy has been mitigated by evidence of emerging mechanisms of resistance
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