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Image-based measurements demonstrated that tumors in the HBSS control group continued to grow, with a mean fold increase of 1.0 relative to their time-zero (Tz) size

Biomed Pharmacother 2001;55:38190

Receptor proximal assays can include cAMP response measurements, calcium flux assays where applicable, recruitment assays that track pathway engagement, and internalization or trafficking readouts that inform residence and persistence

In addition, due to the long-acting properties of YEZTUGO, alternative forms of PrEP should be considered following discontinuation of YEZTUGO for those individuals with HIV-1 negative status who are at continuing risk of HIV-1 acquisition and initiated within 28 weeks of the last YEZTUGO injection [see Warnings and Precautions (5.3)]