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Due to the emerging role of NAD homeostasis in aging and age-related diseases, our discovery of the role of CD38 in the control of cellular NAD levels opens the possibility that CD38 inhibition may be used as a therapeutic approach to increase cellular NAD levels (Figure 1)[1-4, 6]

Cell line culture and macrophage polarization RAW 264.7 macrophage-like cells, obtained from the cell bank of Chinese Academy Sciences (Shanghai, China), were cultured as described previously [31]

Allergic children have more numerous and severe respiratory infections than non-allergic children

These fragments are not biologically neutral