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Cysteine deprivation is linked to ferroptosis, a non-apoptotic form of cell death that involves lipid peroxidation 31

Flexicaulin triggers ROS/ASK1/JNK activation in esophageal cancer, 412 while Quercetin induces AMPK-, ASK1, and p38/caspase-dependent apoptosis
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This mechanism ensures that in the absence of oxidative stress or other stimuli, the expression of NRF2-dependent antioxidant genes is suppressed [88, 90]
Autoimmune diseases such as celiac disease, Rheumatoid arthritis and lupus etc
