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This Cu 2+ -cuprizone complex could not cross the intestinal epithelial barrier in an ex vivo experiment on mice intestines, which was thought to cause systemic copper deficiency [92]
WTX and PALB2 may suppress carcinogenesis partly through maintaining the Nrf2 activity for cytoprotection

CFTR is an ATP-controlled ion channel that moves chloride and bicarbonate ions out of the cell to help maintain hydration of the airway (Bear et al., 1992)